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M94A3065.TXT
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1994-10-25
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Document 3065
DOCN M94A3065
TI ALT as a marker for hepatitis B and C in drug users.
DT 9412
AU Brooks K; Orr S; Fenaughty A; Fisher D; Center for Alcohol & Addiction
Studies, University of Alaska,; Anchorage.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):161 (abstract no. PB0072). Unique
Identifier : AIDSLINE ICA10/94369510
AB OBJECTIVE: To assess the usefulness of alanine transaminase (ALT) as a
surrogate marker for detecting hepatitis C and hepatitis B in the sera
of intravenous drug users (IVDUs) and crack cocaine smokers. METHOD:
Data were collected from the Risk Behavior Assessment (RBA), a
structured interview, which was administered to subjects who tested
positive by the ONTRAK (Roche Diagnostics Systems) urine test for
cocaine, amphetamines, or opiates and/or had track marks. In addition,
subjects must not have been in drug treatment during the prior 30 days.
Sera were collected from 125 subjects and tested for ALT by an enzymatic
kinetic method. RESULTS: Regression analysis results indicated that
individuals who had injected drugs within the last 30 days had
significantly higher ALT levels than those who did not inject. Other
variables, such as if the subject was homeless or if they had ever been
in a drug treatment program, were marginally significant. Subjects who
were negative for antibodies to the hepatitis B core antigen (anti-HBc)
had a mean ALT of 35 units/liter (u/l) versus 58 u/l for subjects
positive for anti-HBc. Subjects negative for antibodies to hepatitis C
virus (anti-HCV) had a mean ALT of 58u/l versus 67 u/l for subjects
positive for anti-HCV. CONCLUSIONS: ALT has long been used as a
surrogate test for hepatitis. This study suggests that it is a useful
marker especially when used with predictors for detecting positivity of
HCV and HBV.
DE Alanine Aminotransferase/*BLOOD Biological Markers Hepatitis
B/*DIAGNOSIS/ENZYMOLOGY/TRANSMISSION Hepatitis
C/*DIAGNOSIS/ENZYMOLOGY/TRANSMISSION Human Risk Factors Substance
Abuse, Intravenous/COMPLICATIONS/*ENZYMOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).